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<includeonly>''Main Article: [[Plague]]''</includeonly>The '''Plague''' is a [[Death|deadly]] [[disease]] that affects both humans and animals. It progresses at a fast rate, killing untreated creatures within days from discovery. It can be caught in any [[Biomes|biome]].
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<includeonly>''Main Article: [[Plague]]''</includeonly>
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__NOTOC__
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'''Plague''' is a [[disease]] in RimWorld which can be caught by your colonists. As of Alpha 16, the Plague is significantly more deadly than it used to be, and having a somewhat skilled doctor and medicine on hand is critical to one's survival. The Plague also causes a strong penalty to colonist mood as it causes a considerable amount of pain, along with the standard 'Sick' thought. It can be caught in ''any'' biome randomly, and you must make sure that afflicted victims get treatment '''ASAP''', and that they remain in bed while developing immunity. The bonus [[Immunity Gain Speed|immunity gain speed]] could mean the difference between life and death.
  
==Overview==
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As the plague progresses at an alarming rate, it can kill an untreated colonist in a mere 1.5 days from discovery. <br>
{{TOCright}}Plague is a disease that is rapidly fatal for humans. If left untreated, it kills in 1.5 days, but rest and good treatment can slow the disease to the point where it takes 3 days to kill. It takes around 2.121 days to develop immunity to the plague - assuming the affected colonist is rested in an ordinary bed for the whole time, has normal blood filtration, is well-fed, and under the age of 40. Animals are more resistant to the disease, but still need treatment.
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Good treatment can slow the disease to the point where it takes 6 days to kill.
  
A skilled doctor, medicine, and healthy [[Blood Filtration]] organs ([[kidney]]s and [[liver]]) are critical to survival. The bonus [[Immunity Gain Speed|immunity gain speed]] could mean the difference between life and death.  
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It takes around 2.121 days to develop immunity to the plague; assuming the affected colonist is rested in an ordinary bed for the whole time, has normal blood filtration, is well-fed, and under the age of 40.
  
=== Prevention ===
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==Stages==
[[Penoxycyline]] prevents colonists from falling sick to the Plague, but does nothing to stop an infection already in progress.
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These are the following stages in which the Plague will progress through, and the effects it has on the victim:
  
== Stages ==
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'''Minor (Hidden) - Severity: 0.01 - 0.39'''
Extreme (Initial) and Extreme (Advanced) both display as just "Extreme" ingame, but have different symptoms.
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*No effects on the affected colonist
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*Buildup to the initial 40% disease head start that the plague has
  
====Minor====
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'''Minor - Severity: 0.4 - 0.59'''
* {{++|20%}} [[Pain]]
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*+20% Pain
* {{--|5%}} [[Consciousness]]
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*-5% Consciousness
* {{--|5%}} [[Manipulation]]
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*-5% Manipulation
  
====Major====
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'''Major - Severity: 0.6 - 0.79'''
* {{++|35%}} [[Pain]]
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*+35% Pain
* {{--|20%}} [[Consciousness]]
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*-20% Consciousness
* {{--|20%}} [[Manipulation]]
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*-20% Manipulation
  
====Extreme (Initial)====
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'''Extreme (Initial) - Severity: 0.8 - 0.9'''
* {{++|60%}} [[Pain]]
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*+60% Pain
* {{--|30%}} [[Consciousness]]
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*-30% Consciousness
* {{--|30%}} [[Manipulation]]
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*-30% Manipulation
  
====Extreme (Advanced)====
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'''Extreme (Advanced) - Severity 0.91 - 1'''
* {{++|85%}} [[Pain]]
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*+85% Pain
* {{--|30%}} [[Consciousness]]
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*-30% Consciousness
* {{--|30%}} [[Manipulation]]
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*-30% Manipulation
* {{--|15%}} [[Breathing]]
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*-15% Breathing
* [[Death]] at 1 severity.
 
  
== Progression ==
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===Progression===
===Stages===
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*When not immune, severity increases by 0.4 per day.
This disease is detected immediately. Severity goes up over time, and is slowed by treatment until immunity is reached.
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*When immune, severity decreases by 0.2 per day.
*Minor - Severity: 0 - 0.59
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*Immunity increases by 0.3 per day when sick.
*Major - Severity: 0.6 - 0.79
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*Treatment slows progression by a maximum of 0.3 per day.
*Extreme (Initial) - Severity: 0.8 - 0.9
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**This means the disease will progress by 0.1 per day at this rate.
*Extreme (Advanced) - Severity 0.91 - 0.99
 
*Death - Severity 1
 
  
===Humans===
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==Defeating the Plague==
*When not immune, severity increases by 0.666 per day.
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As with any other disease, you'll want to ensure colonists afflicted with the plague get as much bed rest as possible. You can prioritize this on colonists by designating a bed as a medical bed, selecting the afflicted pawn, right clicking the bed, and selecting 'Rest until Healed'. You'll want to ensure that the affected colonist(s) get the best medical treatment they can possibly get - don't be afraid to use that Glitterworld Medicine if you have some laying around.  
*When immune, severity decreases by 0.333 per day.
 
*Immunity increases by 0.5224 per day when sick.
 
*Treatment slows progression by a maximum of 0.3628 per day.
 
**This means the disease will progress by 0.3032 per day at 100% tend quality.
 
  
===Animals===
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You can also administer [[Drugs#Penoxycyline|Penoxycyline]], which boosts the immunity up to 61% (As of Alpha 16).
Animals can face the same disease, but their immunity increases faster, and treatment slows progression more.
 
*When not immune, severity increases by 0.666 per day.
 
*When immune, severity decreases by 0.333 per day.
 
*Immunity increases by 0.6092 per day when sick.
 
*Treatment slows progression by a maximum of 0.4254 per day.
 
**This means the disease will progress by 0.2406 per day at 100% treatment.
 
  
== Treatment ==
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===Treating Normal People (<40 Years Old)===
Ensure the afflicted pawns get as much bed rest as possible by prioritizing 'Rest until Healed', and get them the best medical treatment available. For humans, treatment is administered once every 15 hours. For animals, treatment is administered every 48 hours (2 days).
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You need at least 40%+ average treat quality to slow the Plague's progression down sufficiently so that it doesn't kill the victim.
  
On a constantly resting, well-fed pawn with 100% [[Immunity Gain Speed]], you'll need at least 15% average treatment quality to slow the plague's progression down sufficiently so that it doesn't kill the victim.
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The following combinations of doctoring skill and medicine are capable of achieving 40% treatment quality (assuming a perfectly healthy, unmodified doctor, the patient is rested and well-fed at all times, below the age of 40, and treatment is administered immediately) - you'll generally want to aim above these thresholds for safety though; these combinations are just the bare minimum required, and aren't guaranteed to work out:
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*Level 1 Medicine skill and [[glitterworld medicine]]
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*Level 4 Medicine skill and standard [[medicine]]
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*Level 8 Medicine skill and [[herbal medicine]]
  
=== Vulnerable ===
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===Treating the Elderly (80+ Years Old)===
For humans with a base [[Immunity Gain Speed]] of 47% or less, there is no chance that they will be able to survive the plague normally, even with 100% treatment quality for all treatments and rest in a [[hospital bed]] with [[vitals monitor]] connected. This includes very old people over the age of 120, and some people with kidney and liver damage (physical or chemical). A colonist with poor rest or treatment quality may also be on the verge of death.
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It's notably more difficult to treat the elderly as they only gain immunity at 80% of the standard rate - unless they have improved blood filtration. Your doctors will need to be capable of administering an average of 65%+ treatment quality in order for your elderly to survive. Again, this is the bare minimum figure and doesn't take into account the time to reach the medicine and the patient - so you'll generally want to aim above this.
  
To save a colonist on verge of death, you can do the following:
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The following combinations of doctoring skill and medicine type are capable of administering 65% treatment quality:
*Administer [[healer mech serum]] - instantly treats the disease
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*Level 3 Medicine skill and glitterworld medicine
*Administer [[luciferium]] - if pawn has 28% or more immunity gain speed remaining initially, this gives pawn a chance to survive
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*Level 8 Medicine skill and standard medicine
*Use the medic cycle of the [[Biosculpter pod]]{{IdeologyIcon}} - if used early enough, the pawns can bring themselves to it
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*Level 15 Medicine skill and herbal medicine
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If high quality treatment is not available, consider administering [[luciferium]] to the patient, which will dramatically boost their blood filtration and thus rapidly achieve immunity.
  
 
<noinclude>{{Nav/disease}}</noinclude>
 
<noinclude>{{Nav/disease}}</noinclude>
[[Category:Disease]]
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[[Category: Disease]]

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