Paralytic abasia is a long-lasting disease that causes total paralysis.
It doesn't appear on its own, but rather as part of quests if you have the Royalty DLC installed.
The only stage is complete paralysis, with moving set to 10% maximum.
Every day, the disease has a 1% chance of resolving on its own.
A complete cure is expensive, requiring 10 glitterworld medicine and a doctor with medical skill 5 or above.
Other than this, there is no treatment that can relieve symptoms or accelerate disease progression using conventional means.
Added at some point in 1.1.
Prior to 1.1.2654, the disease existed in the basegame and was fully functional, but did not appear in regular, unmodded gameplay.