Topic on Talk:Genes
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Any smokeleaf/alcohol/psychite impervious genes all provide blanket immunity from any drug tolerance gain. Any psychite/wakeup/go-juice impervious genes provide blanket immunity from any drug OD gain via normal means. Or at least force a pawn with psychite impervious to take 2000 wakeup and 500 go-juice wasn't enough to trigger even a minor OD. Average ODs for the amount of drugs they took should have been ~12. Impervious genes addiction immunity is the only part that isn't global it seems (addictions to go-juice and wakeup occurred quite quickly in the test)
Repeating the test with go-juice immune for 1000 wakeup also resulted in no ODs.